Abstract

ANTIBIOTIC SUCEPTIBILITY OF EXTENDED SPECTRUM BETALACTIMASE [ESBL] PRODUCING ESCERICHIA COLI.

Abdulghani Mohamed Alsamarai*, Ibraheem Abdul-Rahman Latif and Mohamed Mohsen Abdul-Aziz

ABSTRACT

Background: ESBL E.coli producers prevalence increased worldwide and contributed to epidemiological changes in urinary tract infection pattern and interfere with management of urinary tract infection. Aim: to determine the frequency ESBL producing E. coli and clarify their susceptibility to antibiotics. Materials and Methods: Urine samples cultured on MacConkey and blood agar. Bacterial isolates identification, antibiotics susceptibility and ESBL were determined using VITEX 2 system. Results: All E. coli isolates were resistant to Ampicillin, Mezlocilin and Piperacillin, while all were sensitive to Ertapenem, Fosfomycin and Tigecycline. Although, this study shows that ESBL producing E. coli uropathogen isolates was high [61.5 %, 32/52], however, the rate was within the range reported globally. ESBL producing E. coli shows maximum resistance to Ampicillin, Cefazolin, Cefepime, Cefotaxime, Tetracycline, Mezlocilin, Piperacillin, Cefuroxime (100%) and ceftazidime (93.7%) while minimum resistance was to Ertapenem, Tigecycline, Fosfomycin (3.1%), Imipenem (6.2%) and Amikacin, Nitrofurantion (9.6%). ESBL producing E. coli was with higher rate of resistance as compared to ESBL negative E. coli. Conclusion: The high rate of ESBL E.coli producer’s isolates is a community and nosocomial health problem that associated with emergence of antimicrobial resistance which attributed to treatment failure of UTI and recurrent infections. High rate of resistance to common antimicrobial agents that form the first and second line of UTI treatment illustrate the importance of determination of ESBL production especially in cases with poor prognosis or with recurrent infections.

Keywords: Urinary tract infection, UTI, ESBL, E. coli, antibiotic susceptibility.