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  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

PILOT STUDY FOR 7.5 MG CAPSAICIN TABLETS AND VALIDATION OF ANALYTICAL METHOD FOR THE QUANTIFICATION OF CAPSAICIN IN HUMAN PLASMA BY LIQUID CHROMATOGRAPHY OF HIGH-RESOLUTION FLUORESCENCE DETECTOR

Dr. Gilberto Quiñonez Palacio, Dr. Jorge Alvelais Palacios,
QFB. David Vargas Torres, QFI. Francisco Gómez Hernández,
*Dr. Gilberto Quiñonez Palacio

ABSTRACT

Objective: To determine concentrations of capsaicin in human plasma by means of an analytical method by HPLC with fluorescence detector. Methodology: Design of single-dose, with 14 subjects under fasting conditions 1 period, 1 open sequence, randomized, comparative and prospective, the approximate retention times were capsaicin 6 minutes and naproxen 4 minutes. Results: During the next three hours twelve volunteers (85.7%) refered epigastric pain not obtaining results of the 14 samples for the determination of capsaicin in human plasma by HPLC-FLD method. Conclusions: Oral administration in tablets is not an alternative to prescribed capsaicin, the method proved to be robust, coefficients of variation less than 3.0%, performance parameters validate the HPLC-FLD method, for the determination of capsaicin in human plasma.

Keywords: capsaicin, neuropeptides, HPLC.


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