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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Invited to submit your valuable manuscripts for Coming Issue.

Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

PILOT STUDY FOR 7.5 MG CAPSAICIN TABLETS AND VALIDATION OF ANALYTICAL METHOD FOR THE QUANTIFICATION OF CAPSAICIN IN HUMAN PLASMA BY LIQUID CHROMATOGRAPHY OF HIGH-RESOLUTION FLUORESCENCE DETECTOR

Dr. Gilberto Quiñonez Palacio, Dr. Jorge Alvelais Palacios,
QFB. David Vargas Torres, QFI. Francisco Gómez Hernández,
*Dr. Gilberto Quiñonez Palacio

ABSTRACT

Objective: To determine concentrations of capsaicin in human plasma by means of an analytical method by HPLC with fluorescence detector. Methodology: Design of single-dose, with 14 subjects under fasting conditions 1 period, 1 open sequence, randomized, comparative and prospective, the approximate retention times were capsaicin 6 minutes and naproxen 4 minutes. Results: During the next three hours twelve volunteers (85.7%) refered epigastric pain not obtaining results of the 14 samples for the determination of capsaicin in human plasma by HPLC-FLD method. Conclusions: Oral administration in tablets is not an alternative to prescribed capsaicin, the method proved to be robust, coefficients of variation less than 3.0%, performance parameters validate the HPLC-FLD method, for the determination of capsaicin in human plasma.

Keywords: capsaicin, neuropeptides, HPLC.

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