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Abstract

STUDIES ON INCLUSION COMPLEXES OF SOME 4- ARYLIDENAMINO-5-PHENYL-4H-1, 2, 4-TRIAZOLE-3-THIOLS

Sashikanta Nayak, Manjula Badatya, Sangita Kumari Swain, Bamakanta Garnaik*

ABSTRACT

The inclusion complexes of some 4-arylidenamino-5-phenyl-4H-1, 2, 4-triazole-3-thiols have been prepared with β-cyclodextrin so as to increase their solubility and bioavailability. The inclusion complexes have been characterized by studying changes in their physical and spectral properties before and after inclusion complexes formation. The thermodynamic stability constant and free energy of activation have been determined to know the stability of inclusion complexes and type of host-guest relation. Finally, the compounds and their inclusion complexes are screened for antibacterial and anthelmintic activities. It is found that inclusion complexes of the newly synthesized compounds have appreciable stability in the cavity of β-cyclodextrin and inclusion complex formation increases their antibacterial and anthelmintic activities significantly as compared to naked compound.

Keywords: Triazole-3-thiol, Inclusion complex. Antibacterial activity, Anthelmintic activity.


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