Abstract

EXTRACTION AND CHARACTERIZATION OF XYLOGLUCAN (TAMARIND SEED POLYSACCHARIDE) AS PHARMACEUTICAL EXCIPIENT

Abeer Bashir*, Pramod Kumar Sharma and Musarrat Husain Warsi

ABSTRACT

Recent study includes extraction and characterization of the xyloglucan from tamarind (Tamarindus indica) seed polysaccharide as a pharmaceutical agent. Tamarind seed polysaccharide was obtained by water based extraction in Soxhlet apparatus. For characterization of the extracted tamarind seed polysaccharide phytochemical screening was done and micromeritic properties, flow behavior and swelling index were determined. It was also found that extracted tamarind seed polysaccharide had good flow properties and pH was 6.4, this showed that it can be used in dosage form, without any irritation. Mucoadhesive nature of extracted tamarind seed polysaccharide was also evaluated by texture analyzer in different concentration range (0.5% and 1%, w/v) and results revealed that it shows concentration based mucoadhesive strength. It can be concluded that tamarind derived seed polysaccharide (xyloglucan) can be used as pharmaceutical agent to prepare different types of formulations.

Keywords: Tamarindus indica, Mucilage, Xyloglucan, Natural polysaccharide, Mucoadhesion.