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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

FORMULATION AND EVALUATION OF FEXOFENADINE HYDROCHLORIDE RAPID DISPERSIBLE TABLETS

*K.Vidyadhari, P.Sirisha, Deepthi.V and Balusu. Devaki Devi

ABSTRACT

The purpose of this research work was to establish rapid dispersible Fexofenadine Hydrochloride tablets. The tablets were prepared by direct compression method using various super disintegrating polymers such as Crospovidone, Croscarmellose sodium and Sodium starch glycolate. Tablets were evaluated by different parameters such as hardness, friability, weight variation, in-vitro dissolution studies, content of active ingredient, wetting time and water absorption ratio. The in-vitro release of drug from the formulations was studied using pH 6.8 phosphate buffer and it was found that the prepared tablets were able to produce rapid dissolution activity. T3 formulation containing 1% w/w of Crospovidone was found to be promising and has shown an in vitro disintegration time of 10 sec by increasing super- disintegrant concentration for different formulations; our results reveal that the T3 has shown99.98% drug release in 10 minutes. The selected formulation was subjected to stability studies and the formulation was evaluated for physical parameters like size, colour, hardness, thicknesses were same. The percentage drug content and % cumulative drug release was tested at 30 days, 60 days and 90days.

Keywords: Fexofenadin HCL, Oro dispersible, cross povidone, and direct compression method.


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