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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR THE DETERMINATION OF DIDANOSINE IN PHARMACEUTICAL DOSAGE FORMS

Md. S. Maqsood Ahmed* and I. E. Chakravarethy

ABSTRACT

A simple, accurate, rapid and sensitive method is developed for the estimation of didanosine in bulk and tablet formulation. The method was based on the charge transfer complexation reactions of didanosine as n-electron donor with acceptor, 2,3-dichloro-5,6-dicyano-p-benzoquinone in methanol medium. The absorbance of the highly intensive coloured solution was measured at 435 nm against reagent blank treated similarly. Beer’s law was obeyed in concentration range 20-100 μg/ml for didanosine. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies. The proposed method is simple, rapid, and validated and can be used successfully for routine analysis of didanosine in a pure and tablet dosage form.

Keywords: Ultraviolet-Visible Spectrophotometry, didanosine, 2,3-dichloro-5,6-dicyano-p-benzoquinone, (DDQ), Formulations.


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