Abstract

IN-SITU GELS FOR OCULAR DRUG DELIVERY SYSTEM: AN OVERVIEW

Sable Namita V*, Gondkar Sheetal B, Saudagar Ravindra B

ABSTRACT

Ocular drug delivery systems have been used widely since few years. In the formulation of these systems, a significant challenge to the formulator is to bypass the protective barriers of the eye. Conventional ophthalmic formulations like solution, suspension, and ointment have many disadvantages. These result in poor bioavailability of drug in the ocular cavity and hence formulation scientists are looking for alternatives. Of the various choices available, in-situ gels have shown great promise. The ease of administration and related patient compliance makes in-situ gelling systems an attractive way of tackling with various problems associated with the use of other formulations. This article throws light on the merits of these systems. A good knowledge of the structure and physiology of the eye is necessary for the research and to develop an effective ophthalmic delivery system. Hence, a brief on anatomy and physiology of the ocular cavity has been included. Also, method of preparation and some examples of polymers that can be used in these systems have been discussed. An attempt has been made to give details on the evaluation studies of in-situ gelling systems.

Keywords: Ocular drug delivery systems, In-situ gels, Anatomy and physiology of eye, Method, Polymers, Evaluation.