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Abstract

A QUANTITATIVE ANALYSIS OF FAMCICLOVIR IN BULK AND TABLET DOSAGE FORMULATION BY FT-IR SPECTROSCOPY AND UV SPECTROSCOPY AREA UNDER CURVE METHOD

Sandeep P. Gadhwe*, Sagar N. Dhumane, Amey P. Nijsure, Amol T. Gitte, Shivanand K. Wagh and Kishor N. Gujar

ABSTRACT

In this study IR and area under curve method procedures are describe for the quantitative determination of Famciclovir in bulk and solid dosage form. For IR spectroscopic method (KBr disc technique) has been used. The specific absorption bands at 1731 and 1746 cm-1 were chosen as C=O stretching mainly for Ester respectively. In this method, beer’s law was obeyed in the concentration range 0.8–2.0% w/w in KBr disc. The regression equation was found to be y= 0.195x+0.037 with correlation coefficient 0.998, and the assay was found to be 98.5% with %RSD of 1.023%. The UV spectroscopic area under curve method was also used in the quantitative determination of Famciclovir in solid dosage form. Quantitative determination of the drug was performed at wavelength range 212-232 nm. The linearity was established over the concentration range of 2.5-15μg/ml for Famciclovir with regression equation y= 0.195x+0.037 and correlation coefficient 0.9988. The assay was found to be 98.901% with Precision studies showed that % relative standard deviation was within range of acceptable limits. The mean percentage recovery was found to be 99.905%.

Keywords: Famciclovir, FT-IR, Base-line Technique, Area under curve, Validation.


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