Abstract

A REVIEW ON GELS AS A NASAL DRUG DELIVERY SYSTEM

Patil Devayani R*, Saudagar Ravindra B

ABSTRACT

Nasal mucosa has been considered as a potential administration route to achieve faster and higher levels of drug absorption. This is because the nasal mucosa is permeable to more compounds than the gastrointestinal tract due to lack of pancreatic and gastric enzymatic activity, neutral pH of the nasal mucus and less dilution by gastrointestinal contents. It is easily accessible and suitable for selfmedication. During the past several decades, the feasibility of drug delivery via the nasal route has received increasing attention from pharmaceutical scientists and clinicians. Many review articles describing the anatomy and physiology of human nose are available. In this article, along with the anatomy and physiology an attempt has been made to highlight the important technical and pharmaceutically relevant concepts related with drug delivery systems developed for administration through the nasal route. Various factors affecting the success of such delivery systems have been described. The aim of this article is to give the advantages and disadvantages of nasal gels as potential delivery systems.

Keywords: Nasal mucosa, Anatomy and physiology, Nasal gel, Nasal drug delivery system.