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Abstract

DEVELOPMENT AND VALIDATION OF RP - HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF KETOROLAC TROMETHAMINE, CHLORPHENIRAMINE MALEATE AND PHENYLEPHRINE HYDROCHLORIDE

Nikul M. Rahevar*, Mitali H. Jasani, Ankit B. Chaudhary, Parth R. Nayak

ABSTRACT

The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of Ketorolac tromethamine, chlorpheniramine and phenylephrine hydrochloride. The quantification was carried out using C18 column (150 x 4.6mm, 5μm) and mobile phase comprised of Buffer(TBAHS) and Methanol in proportion of 60:40 %v/v The flow rate was 1.0 ml/min and the eluent was monitored at 215 nm. The selected chromatographic conditions were found to effectively separate Ketorolac tromethamine, chlorpheniramine and phenylephrine hydrochloride were 7.743 min, 10.037 min and 13.990 min respectively. Linearity were found to be in the range of 5-15 μg/ml, 2-6 μg/ml and 1.2-3.6 μg/ml for Ketorolac tromethamine, chlorpheniramine and phenylephrine hydrochloride respectively. The percentage recoveries of all the drugs were found to be 99.66%, 99.73% and 100.99% for Ketorolac tromethamine, chlorpheniramine and phenylephrine hydrochloride. The proposed method was found to be fast, accurate, precise, and reproducible and can be used for simultaneous estimation of these drugs in tablet.

Keywords: Ketorolac tromethamine, chlorpheniramine and phenylephrine hydrochloride, Reversed-phase HPLC.


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