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Abstract

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF CHLORTHALIDONE, CILNIDIPINE AND OLMESARTAN IN TABLET DOSAGE FORM

Parth R. Nayak*, Ankit B. Chaudhary and Nikul M. Rahevar

ABSTRACT

The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of chlorthalidone, cilnidipine and olmesartan in tablet dosage form.The quantification was carried out using C18 column (150 x 4.6mm, 5μm) and mobile phase comprised of Buffer, Acetonitrile and TEA in proportion of 80:20:0.1 %v/v/v The flow rate was 1.0 ml/min and the eluent was monitored at 248 nm. The selected chromatographic conditions were found to effectively separate chlorthalidone, cilnidipine and olmesartan were 4.667 min, 6.887 min and 3.807 min respectively. Linearity were found to be in the range of 6.25-18.75 μg/ml, 5-15 μg/ml and 20-60 μg/ml for chlorthalidone, cilnidipine and olmesartan respectively. The percentage recoveries of all the drugs were found to be 100.07%, 98.79% and 100.09% for chlorthalidone, cilnidipine and olmesartan. The proposed method was found to be fast, accurate, precise, and reproducible and can be used for simultaneous estimation of these drugs in tablet.

Keywords: chlorthalidone, cilnidipine and olmesartan, Reversed-phase HPLC.


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