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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

FORMULATION AND EVALUATION OF NOVEL ORODISPERSIBLE DRUG DELIVERY SYSTEM FOR THE ADMINSTRATION OF BROMHEXINE HYDROCHLORIDE

Bhupinder Bhyan*, Sarita Jangra Bhyan, Vivek Chopra and Ravi Berwal

ABSTRACT

The aim of the research work was to formulate and evaluate novel orodispersible delivery of Bromhexine hydrochloride in the form of oral fast disintegrating films. Formulated films offers a various advantages over the liquid formulation of Bromhexine hydrochloride like ease of handling and administration, expected increased bioavailability due to elimination of hepatic first-pass metabolism. These fast disintegrating films were prepared by solvent casting methods using HPMC E-3 and PVP k-30 as film forming polymers. Cardamom extract, sucralose were used as flavoring agent and sweetening agent to impart pleasant taste. To decrease the disintegration time of formulations sodium starch glycolate was used as disintegrating agent. All the prepared novel films formulations (F1-F8) was evaluated for their, weight variations, thickness tensile strength, percentage elongation, folding endurance, surface pH, in-vitro disintegration, drug content, in-vitro drug release. In the time range 40-80 sec all the film formulation was completely disintegrated. Formulations F1 and F2 showed 90% in-vitro drug release within 8 min. The film showed an excellent stability at least for 3 months when stored at 400 C and 75% in humidity.

Keywords: Fast disintegration films, Novel orodispersible delivery, Bromhexine.


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