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Abstract

DEVELOPMENT OF SPECTROPHOTOMETRIC METHOD AND VALIDATION FOR MELATONIN IN TABLET DOSAGE FORM

Veerendra C. Yeligar*, Ravindra G. Gaikwad, Kavita D. Patil, Sanjay S. Patil and Shitalkumar S. Patil

ABSTRACT

A simple, accurate, precise and economic spectrophotometric method is developed for the determination of melatonin (MLT) in tablet dosage forms. The method is based on the formation of pink colour chromogen complex formed by oxidation of melatonin with Ferric citrate in the presence of 1,10-phenanthroline. The colour complex was measured at 510nm. Beers law was observed in the concentration range of 2-20μg/ml with correlation coefficient 0.988. LOQ and LOD was found to be 0.1229, 0.3724respectively. The method was validated for several parameters like accuracy, precision and linearity, LOQ, LOD. The values of relative standard deviation and % recovery were found to be satisfactory, indicating that the proposed method is precise and accurate and can be used for the determination of Melatonin in tablet dosage forms.

Keywords: Melatonin, ferric citrate, Spectrophotometry, 1,10-phenanthroline.


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