Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

PERFORMANCE EVALUATION OF ALCOHOLIC AND NON-ALCOHOLIC SALBUTAMOL AEROSOL FORMULATIONS

Vinod P. Musale* and Dr. Swati C. Jagdale

ABSTRACT

The purpose and interest of this research on the performance evaluation of alcoholic and Non-alcoholic Salbutamol pressurized inhaler. Metered dose inhalers are formulated in solution form or in suspension form. The present study was aimed at comparing two metered dose inhaler formulation containing Salbutamol Sulphate (100 μg) with alcohol and without alcohol. The current study intended to highlight the impact and necessities of alcohol for the manufacturing of Salbutamol Sulphate Inhaler. pMDI is the most common dosage form for inhalation by which the micronized drug is delivered from a pressurized container suspended in a liquefied gas (Propellant- HFA134a/HFA 227ea). Inhalation is the convenient way to deliver drugs to respiratory tract in treatment of respiratory disease like Asthma & Chronic Obstructive Pulmonary Diseases (COPD). The Respirable fraction of the dose is the particles deposited in the respiratory tract after inhalation. Solution formulations of metered dose inhalers of salbutamol sulphate performed better and gave lower mass median aerodynamic diameter (MMAD = 2.692) values as compared to their suspension formulation (MMAD = 3.583). Particle size distributions were compared determining mass balance and fine particle fraction <4.7μm aerodynamic diameter (FPF<4.7μm). Fine Particle Dose (FPD) determined by ACI for Salbutamol solution [F1] and suspension [F2] formulations i.e. 44.9% (47.31 μg/Spray) and 31.5% (34.94μg/Spray) respectively. The determined % Assay of salbutamol formulations shows that, [F2] 110.8% betters than the [F1] i.e. 105.5%. The study shows that the suspension formulation showing better results and the experimental evaluation shows that there is no any effective/major impact of ethanol on the Salbutamol inhaler formulation.

Keywords: Aerosol Formulations, Alcoholic Inhalers, Salbutamol, Suspension and Solution.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More