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Abstract

FORMULATION AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF AMITRIPTYLINE

Gunjan Kalyani*, Baikuntha Adjuad, Din Bandhu Dinanath Baghel, Chandrashekhar Sahu and Rahul Singh

ABSTRACT

Amitriptyline is an antidepressant drug. It elevates mood by raising the level of neurotransmitters in nerves of the brain. It is used to elevate the mood of patients with depression. It may be taken with or without food. The present research work was undertaken with an objective of preparation, formulation and evaluation Amitriptyline tablet by altering different polymers (Xanthan Gum, HPMC, Na-CMC and E.C.) as a trial, for treatment of depression. Primarily tablets were prepared by using wet granulation technique and were evaluated as per Pharmacopoeial specifications. In the preparation of the tablets (XF10) combination of Xanthan gum and ethyl cellulose was used in 60%, magnesium stearate 0.8%, talc 1.2%, PVP K-30 8% and 10% lactose was used and tablets were prepared by wet granulation technique, in which 250 mg strength tablet was prepared with the help of 9 mm diameter punch size and the thickness was found to be 3.5mm. Several batches were prepared to sustain the release of drug. Dissolution study was performed for the tablet and due to presence of Xanthan gum tablet was hydrated, swelled upon contact with aqueous media and released 86% of drug in 10 hrs. The release kinetics was determined for the batches and it was concluded that the tablet followed zero order kinetics with regression value 0.931 and released the drug by diffusion mechanism with regression value 0.957. From the above study it was concluded that Sustained release matrix tablet can be prepared successfully in industrial scale.

Keywords: Amitryptyline, Sustained release dosage forms, Release kinetics, sustained release matrix tablet, Xanthan gum.


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