Abstract

SYNTHESIS OF NOVEL SULTAMS CONTAINING TETRAZOLE HETEROCYCLES

P. Ramesh Babu*, L. K. Ravindranath, D. Rajesh and B. Saritha

ABSTRACT

Novel Tetrazoles Synthesis of Synthesis of 2-(2-(5-phenyl-1H-tetrazol-1-yl)ethyl)-1,2-thiazetidine 1,1-dioxide (9 a-f) were synthesized by condensation reaction between synthesis of 2-(2-(4-substituted benzylideneamino)ethyl)-1,2-thiazetidine 1,1-dioxide 6(a-f) and a mixture of PCl5 and imidoyl chloride. Synthesis of 2-(2-(4-substituted benzylideneamino) ethyl)-1,2-thiazetidine 1,1-dioxide 6(a-f) was condensed with 4-substituted benzaldehyde in absolute alcohol. The synthesis of 2-(2-aminoethyl)-1,2-thiazetidine 1,1-dioxide(4) was synthesized by condensation of synthesis of 1,2-thiazetidine 1,1-dioxide (β-Sultam)(3) a mixture of K2CO3, TEBA, Acetonitile and 2-chloro ethanamide. Synthesis of 1,2-thiazetidine-1,1-dioxide(β-Sultam) (3) was synthesized with Taurinesulfonylchloride (2) with Na2CO3, Ethyl acetate. Taurinesulfonylchloride (2) was synthesized by S-S bond cleavage Cystaminedihydroxychloride (1) with mixture of Chlorine gas, Chloroform and Ethanol solvent mixture.

Keywords: Sultam, Tetrazole, Cylization, Antibacterial and antifungal activity.