Abstract

CHRONOMODULATED DRUG DELIVERY SYSTEM: A REVIEW

Shilpi Kashyap*

ABSTRACT

In this review, the concepts of biological rhythms, chronobiology, chronopharmacology and chronotherapy for various diseases have been discussed. Chronopharmaceutical Drug Delivery Systems (ChrDDS) is novel system which provides a pattern of real‐time drug input at different release rates and it may be achieved by stimuli‐sensitive and pulsatile drug delivery systems. Drug pharmacokinetics can also be time dependent; therefore, variations both in a disease state and in drug plasma concentration need to be taken into consideration in developing drug delivery systems intended for the treatment of disease with adequate dose at appropriate time. A number of chronotherapeutic medications, aiming at synchronizing medications and the intrinsic biorhythms of disease have been developed by novel drug delivery technology.

Keywords: Chronobiology, Chronomodulated drug delivery system, Circadian rhythm, Pulsatile drug delivery system.