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Abstract

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF COBICISTAT AND DARUNAVIR IN TABLET DOSAGE FORM

Sigamala S. Kumar*, Donthireddy Sai Priyanka and Paul Richards M.

ABSTRACT

A simple, Accurate, precise method was developed for the simultaneous estimation of the Cobicistat and Darunavir in Tablet dosage form. Chromatogram was run through BDS (250mm 4.6mm, 5μ). Mobile phase containing Buffer and Acetonitrie in the ratio of 40:50A:10M was pumped through column at a flow rate of 1ml/min. Temperature was maintained at 30°C. Optimized wavelength for Cobicistat and Darunavir was 210nm. Retention time of Cobicistat and Darunavir were found to be 3.170 min and 3.984 min. %RSD of the Cobicistat and Darunavir were and found to be 1.06 and 1.3 respectively. %Recover was Obtained as 100.71% and 100.2% for Cobicistat and Darunavir. LOD, LOQ values were obtained from regression equations of Cobicistat and Darunavir were 0.107 ppm, 0.326 ppm and 0.333ppm, 1.009 ppm respectively. Regression equation of Cobicistat is y = 10306x + 1346, and of Darunavir is y = 8883.x + 2152.

Keywords: Cobicistat, Darunavir, RP-HPLC.


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