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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

DEVELOPMENT, CHARACTERIZATION AND EVALUATION OF THE PIROXICAM NANOEMULSION GEL AS TOPICAL DOSAGE FORM

Hayder Kadhim Drais*

ABSTRACT

Piroxicam is a non-steroidal anti-inflammatory drug. It is practically insoluble in water. It is associated with many gastrointestinal unwanted effect. The objective of this investigation to prepare an evaluate nanoemulsion gel of piroxicam as a topical dosage form to increase solvability of piroxicam and decrease the gastrointestinal side effect that lead to enhance piroxicam bioavailability and therapeutic activity. The pseudoternary phase diagrams were constructed from the double distilled water, surfactant mixture (Smix) was tween 80 and ethanol at ratios of (1:1, 2:1, 3:1, and 4:1) and oil mixture. The pseudoternary phase plot that has larger region of nanoemulsion was Smix ratio (3:1) from which take six of nanoemulsion formulas (NE1-NE6) for characterization of nanoemulsions and to formulate nanoemulsion gel formulas (NF1-NF6). The six of nanoemulsion gel formulas were evaluated. NF6 was the optimized formula and tested for stability and morphology. Atomic force microscopy (AFM) shows that the selected formula (NF6) is highly stable. It can be concluded that the selected (NF1) was an effective alternative for the topical delivery of piroxicam.

Keywords: Nanoemulsion, Piroxicam, Nanoemulsion gel.


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