Abstract

TOXICOLOGICAL EVALUATION OF SOME NOVEL OXAZOLONE DERIVATIVES

*Sreemoy Kanti Das¹, Ayan Majumdar²

¹Faculty of Pharmacy, S. Sinha College, Aurangabad, Bihar, India.
²Himalayan Pharmacy Institute, Majhitar, East Sikkim, India.

ABSTRACT

All new pharmaceutical drugs are tested for their safety prior to their use in human volunteers and patients. A key stage in ensuring the safety of drugs is to conduct toxicity study in appropriate animal models. In the present study the toxicological profile of some novel oxazolone derivatives was evaluated. Three derivatives viz: OXZ- 1,OXZ-2,OXZ-3 were screened for their Acute and sub acute toxicity. Seed bioassay was also used as an alternative to animal experimentation. Various parameters were observed such as Body weight, Organ weight, haematology and biochemical analysis during the study. Histopathological studies of liver, kidney and heart were also performed to determine the toxicity of the derivatives. All the three derivatives were found to be non toxic having LD 50 value above 5000mg/kg. The hematological parameters of oxazolone treated rats at the dose of 1000 mg/kg p.o. shown increase in total WBC count and increase in Platelets count. The results of histopathology of heart, liver and kidney were intermediary. Altogether it can be concluded that the Oxazolone derivatives were nontoxic upto a dose of 5000mg/kg.

Keywords: Oxazolone, Acute toxicity, OECD, Biochemical, Histopathology.