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Abstract

PHYTOCHEMICAL AND TOXICOLOGICAL STUDIES OF METHANOL EXTRACT OF AGAVE SISALANA (AGAVECEAE)

*U. M. Jajere., C. Hammuel, M. Mohammed, P.O. Okibe, E.O. Ali., A. Abubakar, N. Aliyu

ABSTRACT

Phytochemical and toxicological studies of the methanol extract of Agave sisalana (Agaveceae) were evaluated. The plant leaf is exploited in folkloric medicine for the treatment of antimicrobial infections such as bacterial conjuctivities, scabies, pesticidal, insecticidal properties were reported from the plant. Standard methods were adopted for phytochemical screening and toxicological study. Phytochemically, the leaf contains alkaloids, flavonoids, saponins (steroids and triterpenes) and cardiac glycosides. Toxicity study of the leaf revealed the median lethal dose (LD50) of 282.84mg/k as moderately toxic. The plant leaf is moderately toxic and could be used in the herbal therapeutic purposes with regulation and quality control process.

Keywords: Phytochemical, Toxicological, Agave sisalana, Agaveceae, Median Lethal Dose.


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