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Abstract

RECENT APPLICATIONS OF SPECTROPHOTOMETRIC AND THIN LAYER CHROMATOGRAPHIC METHODS FOR QUALITY CONTROL OF FIXED DOSAGE COMBINATIONS OF SARTANS WITH HYDROHLORTHIAZIDE

Vladimir P. Yankov, Dobrina D. Tsvetkova*, Danka P. Obreshkova, Stefka A. Ivanova, Valentina B. Petkova

ABSTRACT

The aim of current study is to summarize the application of spectrophotometric and thin layer chromatographic methods for simultaneous determination of sartans and thiazide diuretic Hydrochlorothiazide in fixed dosage preparations. Hypertension is one of the most significant social disease, leading to stroke, myocardial infarction and high mortality. Combination therapy with antihypertensive drugs from different classes: beta-blochers, calcuium antagonists, angiotensine-converting enzyme inhibitors, angiotensine II receptor antagonis (sartans) and duiretics improves blood pressure by synergistic effect. The theatment with fixed-dose formulations in a single-dosage form allows to optimize the blood pressure control. The very modern trends in hypertension therapy is the application of fixed dosage preparations of sartans with a thiazide diuretic Hydrochlorothiazide (HCTZ): Candesartan (Atacand HCT), Irbesartan (Avapro HCT), Olmesartan medoxomil (Benicar HCTZ), Valsartan (Со-Valsacor). For improvement of blood pressure control in hypertension current trends include triple fixed-dose combinations with an angiotensin II receptor blocker, a calcium channel blocker, and a thiazide diuretic. For simultaneous determination of sartans in fixed-dosage formulations with Hydrochlorothiazide are developed different types of spectrophotometric methods: UV, first, second and fourth-derivative and first derivative of ratio spectrophotometry; zero-crossing difference spectrophotometry, simultaneous equation method, absorbance ratio (Q-analysis) and chemometric methods. HPTLC methods with diferrent mobile and stationary phases are reported for simultaneous estimation of fixrd dosage forms. Other chromatographic method like TLC-densitometry is also appled.

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