Abstract

FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF GLIMEPIRIDE BY USING SOLID DISPERSION TECHNIQUE USING GELUCIRES

A. Sambasivarao*

ABSTRACT

Glimepiride is one of the third generation sulfonylurea used for treatment of type 2 diabetes. Poor aqueous solubility and slow dissolution rate of the glimepiride lead to irreproducible clinical response or therapeutic failure in some cases due to sub therapeutic plasma drug levels. In this study solid dispersion of the drug were prepared by melting method and the drug was taken with carrier in the proportions of (1:3, 1:4 and 1:5). The rate of dissolution of Glimepiride was increased with the proportion of (1:5) (Drug: Gelucire 55/18) when compared to the other formulations. Solid dispersions of Glimepiride with Different grades of Gelucire were prepared and further compressed as tablets by using Croscarmellose sodium, Micro crystalline cellulose pH 112, Lactose monohydrate, Hydroxy propyl cellulose, Sodium steryl fumarate and Magnesium stearate. The immediate release tablets were prepared by using SD_3 formulation. F5 is the better formulation when compared to all formulations. The F5 formulation has given 95% drug release in 30mins and it is following the first order kinetics.

Keywords: Solid dispersions, Immediate release, Glimepiride, Gelucire 55/18, Gelucire 44/14, Gelucire 48/16.