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Abstract

SIMULTANEOUS ESTIMATION OF LAMUVIDINE AND STAVUDINE BY RP-HPLC IN TABLET DOSAGE FORM

Donthamalla Gunasheela*, P. Shyam Sunder and V. Rajesh

ABSTRACT

A high-performance liquid chromatographic method was developed and validated for the simultaneous estimation of two antiretroviral drugs viz. Lamivudine and Stavudine that constitute one of the first line regimens in antiretroviral therapy. The different analytical performance parameters such as linearity, precision, accuracy, specificity, were determined according to International Conference on Harmonization ICH Q2B guidelines. Chromatography was carried out by isocratic technique on a reversed-phase BDS HYPERSIL C18 column with mobile phase comprising of 0.1M disodium hydrogen phosphate anhydrous buffer: methanol, adjusted to pH 5 with glacial acetic acid in the ratio of 50:50, v/v and the chromatographic condition was set at a flow rate of 1ml/min with the UV detector at 238 nm. The retention time Lamivudine and Stavudine was 4.8 and 5.7 minute, respectively. The linearity of the calibration curves for each analyte in the desired concentration range is good (r2 > 0.999) by RP-HPLC method.

Keywords: .


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