Abstract

PREPARATION AND EVALUATION OF LAMIVUDINE PRONIOSOMES FOR HIV INFECTION

Meenakshi M.* and K. Elangoo

ABSTRACT

This research work describes the preparation of Lamivudine loaded maltodextrin based proniosomes by slurry method using different non-ionic surfactants (Span 40, Span 60, Tween 60) in various concentrations keeping the concentration of cholesterol, maltodextrin as constant. The interaction between drug and added exicipients were studied by FT-IR. Further proniosomes converted into niosomes by simple hydration method and evaluated for particle size distribution, drug content, entrapment efficiency, in- vitro drug release and kinetic studies. The stability study of optimized proniosomes has been determined as refigerator (40C ± 20C) and room temperature (250C ± 20C). The effect of surfactant concentration on vesicle size, entrapment efficiency and in-vitro drug release were studied. The highest entrapment efficiency was found for formulation FS3 (95.02%). The cumulative percentage drug release in 24 hours was achieve with formulation FS3 (93.53%).

Keywords: Lamivudine, Cholesterol, Maltodextrin.