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Abstract

FORMULATION AND EVALUATION OF IBUPROFEN TABLETS BY USING DIFFERENT SUPERDISINTEGRATING AGENTS

Malla Vasavi Chandrika*, M. Mani Kumari, U. Mariyadas, M. Sushma, N. Mounika

ABSTRACT

The main objective of present investigation is to formulate fast dissolving tablets of Ibuprofen and to evaluate flow, mechanical and release properties of Ibuprofen tablets formulated by using two different super disintegrating agents namely sodium starchglycolate, Croscarmellose sodium, Crospovidone. Total six formulations were prepared by varying the concentrations of super disintegrating agents (2 mg, 4 mg, 6 mg, 8 mg & 10 mg). All the six formulations are having good flow properties and are prepared by direct compression technique. Compatibility studies were conducted by using FTIR and all the excipients used in the formulation were compatible with the drug. All the six formulations shows first order release. The dissolution kinetics was presented in Table 5.4. The dissolution rate followed first-order kinetics (Figure 5.2) as the graphs drawn between log % drug unreleased vs time were found to be linear. The dissolution rate of Ibuprofen was found to be effected by the concentration of the super disintegrating agents used in the preparation of tablets. Based on the dissolution rate, the order of drug release from the four formulations was F6> F5> F4> F3> F2 > F1. The formulation prepared with 10 mg of super disintegrating agents (F6) was offered relatively rapid release of Ibuprofen when compared with other concentrations employed in this investigation.

Keywords: Ibuprofen, sodium starchglycolate, Croscarmellose sodium, Crospovidone, Direct compression technique.


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