WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

METHOD DEVELOPMENT AND VALIDATION OF IBRUTINIB BY RP HPLC IN BULK AND PHARMACEUTICAL DOSAGE FORM.

Vykuntam Uppala, Ayesha Tabassum*, Lavanya K., Neeraja V., JVC Sharma

ABSTRACT

A simple, Precised, Accurate method was developed for the estimation of Ibrutinib by RP-HPLC technique. Chromatographic conditions used are stationary phase Kromosil150mm x 4.6 mm, 5, Mobile phase0.1% OPA: Acetonitrile in the ratio of 40:60and flow rate was maintained at 1ml/min, detection wave length was 296nm, column temperature was set to 30oC and diluent was mobile phase Conditions were finalized as optimized method. System suitability parameters were studied by injecting the standard six times and results were well under the acceptance criteria. Linearity study was carried out between 25% to150 % levels, R2 value was found to be as 0.999. Precision was found to be 1.01 for repeatability and 1.50 for intermediate precision. LOD and LOQ are 0.394μg/ml and 1.194μg/ml respectively. By using above method assay of marketed formulation was carried out 100.55% was present. Degradation studies of ibrutinib were done, in all conditions purity threshold was more than purity angle and within the acceptable range.

Keywords: HPLC, Ibrutinib, Method development. ICH Guidelines.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More