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Sandhiya V.*, Rama B., Shree Krishna M., Dharani, Ubaidulla, Dhunmathi K.


The development of new delivery systems for the controlled release of drugs is one of the most innovative fields of research in pharmaceutical sciences. Nanoparticle is specially designed to release the drug in the target sites. The main objective of this work was to prepare and characterize chitosan loaded lamivudine nanoparticles. The organoleptic property of the drug were complys with USP standard. The solubility studies were performed. The FTIR and DSC studies were carried out for pure drug, polymer and drug with polymer in different ratio which shows there was no chemical interaction between the drug and polymer. The drug content and entrapment efficiency of the nanoparticles was increase as the concentration of polymer increase. The F4 formulation shows more entrapment efficacy compared to other formulations nearly 70.87% and the drug content was found to be 86.7%. The particle size and the surface morphology results revealed that lamivudine nanoparticles (LNPs) were smoothed spheroidal with a size ranging from260 nm-632 nm. The invitro dissolution studies were carried out for all the Formulation. Formulation F4 shows 97.67% of drug release at the end of 24 hr. The results suggest that chitosan polymer based nanoparticulate formulations are potential means to achieve release of lamivudine for the prolonged period of time for effective therapy. The results showed that this method is reproducible easily.

Keywords: Chitosan, Nanopartical, Anti- viral drug.

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