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Abstract

SIMULTANEOUS DETERMINATION OF ESOMEPRAZOLE AND ONDANSETRON IN COMBINED PHARMACEUTICAL DOSAGE FORM USING TWO DIFFERENT GREEN SPECTROPHOTOMETRIC METHODS

Poornima A. N.*, Satishkumar Shetty A., Manzoor Ahmed, Anil Kumar S. M.

ABSTRACT

Two simple, precise and accurate spectrophotometric methods have been developed and validated for the simultaneous Determination of ESOMEPRAZOLE (ESO) and ONDANSETRON (ONDA) in bulk and pharmaceutical formulations. Namely Simultaneous equation (method 1), Q-absorbance ratio (method 2). In method 1, both the drugs exhibit good linearity over the concentration range of 1-50 mg/mL and 1-50 mg/mL of ESOMEPRAZOLE and ONDANSETRON at 302nm (r2 =0.9999 and 0.9998 respectively) and 246nm (r2 =0.9999 and 0.9999 respectively) wavelengths respectively. Method 2, involves the formation of Q-absorbance equation using the absorptivity values at 241nm (isoabsorptive point) (r2 =0.9999 and 0.9999 respectively) and 302nm (λmax of ESOMEPRAZOLE) (r2 =0.9998 and 0.9999 respectively) and Beer’s Lambert’s law was obeyed over the concentration range of 5-25 mg/mL and 2-10 mg/mL respectively. The proposed methods were validated according to ICH guidelines for evaluation of accuracy, precision, sensitivity. These are economically viable methods that do not require any prior separation procedure and costly solvents.

Keywords: Esomeprazole, Ondansetron, Simultaneous equation method, Q-ratio method, Validation.


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