Abstract

CYTOTOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF N-(6-BENZOYL-1H-BENZO [D]IMIDAZOL-2-YL)-2-(2-OXOSUBTITUTED INDOLIN-3-YLIDENE) HYDRAZINE CARBOXAMIDES

B. Shoba Rani*, K. Blessi Priyanka, L. Harikiran and G. Sammaiah

ABSTRACT

In the present study novel series of N-(6-benzoyl-1H-benzo[d]imidazol-2-yl)-2-(2-oxosubstitutedindolin-3-ylidene) hydrazine carboxamides (III a-m) have been synthesized in good yields and characterized by IR, NMR and mass spectral analyses. The compounds were evaluated for their preliminary in vitro cytotoxic activity against HCT-116 (colon ) and HepG2 (hepatocellular) cancer cell lines by standard MTT assay , antioxidant activity by standard DPPH assay method and also were screened for in vitro anti-inflammatory activity by TMPD assay method.

Keywords: benzimidazole, isatin, cyototoxic, anti-inflammatory, antioxidant.