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  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

FORMULATION, OPTIMIZATION AND EVALUATION OF COLON TARGETED DELIVERY SYSTEM FOR ISRADIPINE.

Shweta Gupta and *Rathva Devendra P

ABSTRACT

The aim of the study was to develop an optimal colon targeted tablet of Isradipine, an anti-hypertensive drug in order to prevent hepatic metabolism and also to improve patient compliance. In this study, different diluents (lactose, dicalcium phosphate, calcium carbonate) and disintegrating agents (sodium starch glycolate, starch) were screened to prepare Isradipine core tablet and then polymers (Guar gum, HPMC K4M) were optimized to prepare compression coated tablets. 32 full factorial design was applied by taking amount of Guar gum as X1 factor and amount of rate controlling polymer i.e. HPMC K4M as X2 factor. Ferric oxide Red was used as colorant in compression coating. FT-IR studies revealed that drug was compatible with all the excipients. The optimized batch with X1 (140mg) and X2 (21.875mg) showed 85.95 % Cumulative drug release in 8 hrs. The dosage form was found stable at accelerated conditions of 40°C and 75% RH for 30 days. From the obtained data, it was concluded that the developed colon targeted compression-coated tablets of Isradipine is effective drug delivery system and may be an alternative to conventional dosage form. However, further studies are needed to be performed before this formulation can be commercially exploited.

Keywords: Isradipine, guar gum, HPMC K4M, compression coating, colon targeted drug delivery.


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