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  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

MUCOADHESIVE DRUG DELIVERY SYSTEM: A REVIEW

Khan Shahid*, Verma Mayank, Aggarwal Geeta and Kumar S. L. Hari

ABSTRACT

Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastrointestinal tract (GIT) require increased duration of stay in GIT. Mucoadhesion is currently explained by five theories: electronic, adsorption, wettability, diffusion and fracture. The process of mucoadhesion involving a polymeric drug delivery system is a complex one that includes processes such as wetting, adsorption and interpenetration of polymer chains. Mucoadhesive dosage forms are advantageous in increasing the drug plasma concentrations and also therapeutic activity. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. As such, mucoadhesive systems have found wide use throughout many mucosal covered organelles for active ingredients delivery for local or systemic effect. The administration of drugs by the buccal route has several advantages over per oral administration such as quick action, improved patient compliance particularly with paediatric & geriatric patient. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, and finally various mucoadhesive drug delivery systems.

Keywords: Bioadhesive, Mucoadhesive Polymers, Mucoadhesive Drugs.


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