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  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

A REVIEW ON SOLID SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM: AN APPROACH FOR BIOAVAILABILITY ENHANCEMENT

Sanghmitra N. Shukla*, Dr. Dikshit C. Modi and Dr. Dhiren P. Shah

ABSTRACT

Oral route is the easiest and most convenient way of non-invasive administration. However, the oral drug delivery may hamper drug molecules that exhibit poor aqueous solubility. These drugs are classified as Class II drug by the Biopharmaceutical Classification System (BCS), drugs with poor aqueous solubility and high membrane permeability. Approximately, 40% of new chemical entities exhibit a poor aqueous solubility and present a major challenge to modern drug delivery system which leads to low dissolution, limited absorption, poor oral bioavailability, high intra and inter-subject variability and lack of dose proportionality. Different formulation approaches like micronization, solid dispersion and complexation with cyclodextrin have been utilized to resolve such problems but they have certain limitations such as the main problem associated with micronization is limited chemical and thermal stability, degrade and lose their bioactivity upon micronization. The realization that the oral bioavailability of poorly water soluble drug can be enhanced when co-administered with a meal rich in fat has lead to increase in interest in the lipid based drug delivery system (LBDDS) with particular emphasis on Solid Self-nanoemulsifying drug delivery system.

Keywords: Solid Self- Nanoemulsifying Drug Delivery System, Biopharmaceutical Classification System, Bioavailability, Lipid Based Drug Delivery System.


[Full Text Article]

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