Abstract

INCREASED INFLAMMATORY RESPONSE IN MYOCARDIAL ISCHEMIA-REPERFUSION AND MODULATION OF INFLAMMATORY RESPONSE BY MYRICETIN AND KAEMPFEROL IN NORMAL AND STZ INDUCED TYPE I DIABETIC RATS.

Pottendla Srikanth* and Dr. P. Padmabhushanam

ABSTRACT

Rapidly growing importance of revascularization procedures in the management of myocardial infarction in normal as well as diabetic patients has thrown the ischemiareperfusion injury into the limelight. Myocardial infarction was produced by occlusion of the left anterior descending coronary artery for 30 min followed by 4 h of reperfusion. Myeloperoxidase activity in heart tissue and interleukin-12 levels in serum was estimated to ascertain the involvement of inflammatory mediators and to evaluate the effect of Myricetin and Kaempferol on these mediators. Results indicated that Myeloperoxidase and interleukin-12 levels were increased in myocardial ischemia reperfusion injury in both normal and diabetic rats. Furthermore, Myricetin and Kaempferol ameliorated the inflammatory response by reducing the activity of Myeloperoxidase and interleukin 12 levels. This is the first study to report the involvement of interleukin 12 levels in cardiac ischemia reperfusion injury in both normal and diabetic rats.

Keywords: Ischemia –reperfusion Injury, Type-1 diabetes, Myricetin and Kaempferol.