Abstract

EFFECT OF ANDROGRAPHIS PANICULATA NEES EXTRACTS ON GROWTH OF SOME BACTERIA AND SOME FUNGI

A. Athiseshan*, E. Elakkiya, R. Rahavi, S. Priyadharshini, R. Bharathidasan, L. Prince

ABSTRACT

Antimicrobial activity of Andrographis paniculata Nees. leaf extracts on opportunistic pathogenic microbes, bacteria and fungi was observed in this study. A.paniculata leaves were extracted by using soxhlet apparatus method and three kinds of solvents: acetone, aqueous and methanol. A. paniculata leaf extracts were tested against human pathogenic microbes. Bacteria such as Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Staphylococcus aureus and fungi such as Aspergillus conicus, Aspergillus flavus, Aspergillus niger, Aspergillus sulphureus by agar well diffusion method. All the leaf extracts of A.paniculata exhibited greater activity towards bacteria and fungi. The extract demonstrated higher activities against all the bacteria and fungi tested, with the highest activity (acetone extract of 15 mm zone of inhibition) demonstrated against Salmonella typhi, it was observed that, methanol extracts of whole plant and leaves showed the significant antimicrobial activity against Gram-positive bacteria and (methanol extract of 15 mm zone of inhibition) demonstrated against Aspergillus conicus.A.paniculata may be used for the treatment of fever like ckikunguny, swine –flu, typhoid, snake bite and common cold etc.

Keywords: Andrographis paniculata, Antimicrobial activity, Agar well diffusion, ckikunguny.