COMPARATIVE IN-VITRO PHARMACEUTICAL QUALITY CONTROL EVALUATIONS OF DIFFERENT BRANDS OF IBUPROFEN TABLETS MARKETED IN THE TRINIDAD & TOBAGO, WEST INDIES
Madan Mohan Gupta* and Madhulika Gupta
ABSTRACT
Ibuprofen is an NSAID (non-steroidal anti-inflammatory drug) that is
commonly used for the relief of symptoms of arthritis, fever, primary
dysmenorrhea (menstrual pains) and as an analgesic (a medication
given to reduce pain without resulting in loss of consciousness). The
purpose of this research work was to check, compare and evaluate the
quality standards as per the pharmacopoeia of different brands of
Ibuprofen tablet of 400mg strength available in hospitals and
pharmacies of Trinidad & Tobago. These different brands (A, B, C, D)
of Ibuprofen tablets were tested for weight variation, friability,
disintegration, drug assay and in-vitro dissolution. The evaluation
study was performed as per the United States Pharmacopoeia. The
results shows that all the tablets passed the uniformity of weight (<±
5%), friability (<1%), disintegrates in less than 30 minutes (Ibuprofen
coated tablets) and drug assays shows that amount of drugs varies between 90-100%. The Invitro
dissolution study in phosphate buffer pH 7.2 shows that about 95% drug release in 30
minutes so all these results shows that available ibuprofen 400 mg passes all the
pharmacopoeial tests.
Keywords: Ibuprofen, weight variation, friability, disintegration, drug assay, in-vitro dissolution.
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