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Abstract

COMPARATIVE IN-VITRO PHARMACEUTICAL QUALITY CONTROL EVALUATIONS OF DIFFERENT BRANDS OF IBUPROFEN TABLETS MARKETED IN THE TRINIDAD & TOBAGO, WEST INDIES

Madan Mohan Gupta* and Madhulika Gupta

ABSTRACT

Ibuprofen is an NSAID (non-steroidal anti-inflammatory drug) that is commonly used for the relief of symptoms of arthritis, fever, primary dysmenorrhea (menstrual pains) and as an analgesic (a medication given to reduce pain without resulting in loss of consciousness). The purpose of this research work was to check, compare and evaluate the quality standards as per the pharmacopoeia of different brands of Ibuprofen tablet of 400mg strength available in hospitals and pharmacies of Trinidad & Tobago. These different brands (A, B, C, D) of Ibuprofen tablets were tested for weight variation, friability, disintegration, drug assay and in-vitro dissolution. The evaluation study was performed as per the United States Pharmacopoeia. The results shows that all the tablets passed the uniformity of weight (<± 5%), friability (<1%), disintegrates in less than 30 minutes (Ibuprofen coated tablets) and drug assays shows that amount of drugs varies between 90-100%. The Invitro dissolution study in phosphate buffer pH 7.2 shows that about 95% drug release in 30 minutes so all these results shows that available ibuprofen 400 mg passes all the pharmacopoeial tests.

Keywords: Ibuprofen, weight variation, friability, disintegration, drug assay, in-vitro dissolution.


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