Abstract

SOLID LIPID NANOPARTICLES A POTENTIAL APPROACH FOR DELIVERY OF LIPOPHILIC DRUGS: A REVIEW

Aishwarya T. Nair*, Sanjeevani S. Deshkar, Sahebrao S. Boraste, Roma M. Sharma

ABSTRACT

A pharmaceutical formulation development study requires a detailed understanding of the relationship between the drug entity, excipients, process parameters and its quality attributes. Development of new drug entities is posing real challenge to formulators, particularly due to the poor aqueous solubility of drugs which in turn is a major factor responsible for poor oral bioavailability. To overcome these problems lipid based oral drug deliver system has taken a new dimension with application for lipophilic drugs. One such lipid based system is Solid Lipid Nanoparticles (SLN) in which the lipid serves as a carrier to drugs in their various forms, have the potential of providing endless opportunities to enhance the gastrointestinal solubilization and absorption via selective lymphatic route. The current review discusses the various approaches of lipid drug delivery system, different methods of preparation, characterization and applications of Solid lipid Nanoparticles.

Keywords: Colloidal particles, Nanoparticles, Lipid Based Drug Delivery, Solid Lipid Nanoparticles (SLN).