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Swarupa Arvapally*, N.S. Harika, B. Mounika and S. Spandana


The purpose of present investigation was to develop and evaluate gastroretentive drug delivery system of fluoroquinolone antibiotics (Balofloxacin). These floating tablets were prepared with the objective to obtain site-specific drug delivery and to extend its duration of action. More over the floating system of balofloxacin will provide increased local and systemic action in stomach. Floating effervescent tablets were formulated by various materials like Hydroxypropyl methylcellulose HPMC (K 4M, K100M), Xanthum gum, Microcrystalline cellulose as swelling agent and gas generating agent like sodium bicarbonate. All the formulations were evaluated for floating properties, swelling characteristics and drug release studies. In vitro drug release studies were performed and drug release kinetics evaluated using the linear regression method was found to follow zero order release and non-fickian diffusion mechanism. The floating lag time were found to be significantly increased with the increasing concentration of the polymers. After the dissolution study of prepared balofloxacin floating effervescent tablet it was concluded that the formulation FT4 with HPMCK100 and xanthum gum shows better controlled release effect (98.65%).

Keywords: Balofloxacin, gastroretentive, effervescent floating drug delivery, HPMC (K 4M, K100M), Xanthum gum, Microcrystalline cellulose, sodium bicarbonate.

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