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Abstract

ISOLATION OF QUERCETIN FROM POUTERIA SAPOTA AND EVALUATION OF ITS ANTI OXIDANT AND CANCER ACTIVITIES

K. Kamalakannan, A. Rayar and L. Megala*

ABSTRACT

Natural products including plants, animals and minerals have been the basis of treatment of human diseases. Sapodilla or sapota is a popular delicious tropical fruit in line with mango and kiwi. It has now joined the list of fruits that have proven anticancer properties. People who eat fruits and vegetables have a lower risk of heart disease and some neurological diseases and there is evidence that some types of vegetables and fruits in general, protect against some cancers. Cancer is a class of diseases in which group of cells division beyond the normal limits Invasion and metastasis. Cancer is the third leading cause of death worldwide, preceded by cardiovascular and infectious diseases. The first breast cancer cell line to be established was BT-20 in 1958. Histopathologists recognised that breast cancer was heterogeneous through morphological observations. Free radicals are types of Reactive Oxygen Species (ROS), which include all highly reactive, oxygen-containing molecules. Types of ROS include the hydroxyl radical, the super oxide anion radical, singlet oxygen, nitric oxide radical, hypochlorite radical and various lipid peroxides. Supplementation of antioxidant is widely used in attempts to prevent the development of cancer, it has been proposed that antioxidants may, paradoxically, interfere with cancer treatments. The isolation of organic compound from Pouteria sapota was subjected to column chromatographic separation analysis. The isolated Quercetin was characterized by UV, IR, 1H- NMR and 13CNMR. The MTT assay results for 24 hrs and 72 hrs incubation of Quercetin and EPS at the concentrations 1000,500,250,125 and 62.5% showed increased Breast cancer (MCF-7) cell viability as the concentration got diluted. Quercetin showed significantly higher inhibition percentage at concentration 1000 μg/ml (61.47 ± 0.044) than EPS (45.55 ± 0.041) and positively correlated with total phenolic content. Results of this study suggest that Quercetin is capable of donating hydrogen to a free radical to scavenge the potential damage than EPS. The obtained results might be considered sufficient to further studies for the isolation and identification of some other bioactive principles responsible for the antioxidant activity of EPS.

Keywords: Pouteria sapota; Anticancer; Antioxidant; Quercetin; Human Breast cancer.


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