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Abstract

THE EFFECT OF METHANOL EXTRACT OF TALINUM TRIANGULARE ON SOME SELECTED HEMATOLOGICAL AND KIDNEY PARAMETERS OF EXPERIMENTAL RATS

Ezekwe C.I.*, Okoro Ikechukwu J., Ugwu Okechukwu P.C. and Ezea S.C.

Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

ABSTRACT

This study investigated the effect of methanol extract of Talinum triangulare plant on the blood and kidney of experimental albino rats within a period of two weeks of treatment with (100, 200 and 400mg/kg body weights of the extract). Sixteen wistar albino rats weighing between 117- 200g were randomly divided into four groups. The control group received normal saline while the three other groups received the extract at varied dose levels of (100, 200 and 400mg/kg body weight). Results of serum PCV and RBC indicated a significant increase (p<0.05) while there was no significant difference between serum urea and creatinine when compared to the control. The qualitative phytochemical and chemical screening revealed the presence of alkaloids, flavonoids, glycosides, reducing sugars, saponins, proteins, carbohydrate, fats and oil, tanins, steroids, resins and terprenoids in the methanol extract of the plant. Therefore, this study suggests that methanol extract of Talinum triangulare leaves have phytochemical ingredients capable of improving the kidney and blood of individuals and thus, might be useful in the management of anaemia or kidney related disorders caused by erythropoietin suppression.

Keywords: phytochemical, erythropoietin, anaemia, Talinum triangulare, Heamatological parameters and kidney markers.


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