Abstract

IN VIVO STUDIES ON AQUEOUS EXTRACT OF GUM RESIN OBTAINED FROM COMMIPHORA WIGHTII FOR THE TREATMENT OF PEPTIC ULCER

Sumit Kumar* and Sudhir Kumar Singh

ABSTRACT

The objective of this study was to investigate the Antiulcer activity of gum resin of Commiphora wightii (bhandaari) in rats. The antiulcer activity of aqueous extract was evaluated in indomethacin & ethanol induced gastric ulcer model in wistar rats. The aqueous gum resin extract was prepared by cold maceration extraction process using water as solvent. Phytochemical analysis & acute oral toxicity were carried out using standard methods. The preliminary phytochemical screening of C.wightii revealed the presence of sterols, glycoside & flavonoids. The Aqueous extract at a concentration of 250 mg/kg & 500 mg/kg exhibit a protective effect on ulcer induced models & was compared with standard drugs Ranitidine & Misoprostol. Percentage ulcer inhibition of aqueous Extract at 500 mg/kg for Indomethacin & ethanol induced ulcer model were 23.27% & 40.55% respectively. Among the doses studied aqueous extract 500 mg/kg body weight was found to be optimum for significant ulcer reduction. The flavanoids & Sterols present in the aqueous extract might be responsible for the antiulcer action probably by maintaining the antioxidant level in the gastrointestinal tract there by reducing mucosal damage. The extract exhibit ulcer protection activity in dose dependent manner

Keywords: Antiulcer activity, Ranitidine, Misoprostol, Ulcer Index, C.wightii.