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Abstract

COMPARISION OF ANTI FUNGAL ACTIVITY IN KETACONAZOLE AND GRISEOFULVIN NIOSOMAL GEL

A. Aruna*, S. Mohamed Halith, A. Abirami and K. Jeya Sundari

ABSTRACT

The present study is to develop a targeted delivery to the fungal affected cells. Niosomes of Ketaconazole and Griseofulvin were formulated by thin film hydration technique using the non-ionic surfactant and cholesterol with constant drug concentration. Ketaoconazole and Griseofulvin niosomal gel were tested for invitro anti fungal activity using the strain Aspergillus niger and Candida albicans. All the niosomal formulations showed gradual increase in zone of inhibition. Result of the present investigation indicates the best formulation of ketaconazole niosomal gel posses great anti fungal activity, against the candida albicans.

Keywords: Aspergillus niger, candida albicans, niosomal gel.


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