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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

DEVELOPMENT OF CONTROLLED DRUG DELIVERY SYSTEM OF WATER SOLUBLE DRUG AND ITS INVITRO EVALUATION

Faizan Sayeed*, Gopal Garg and Ab. Sayeed

ABSTRACT

The purpose of the present study was to design, development, formulation and evaluation controlled release matrix tablets for an antiasthmatic drug, Theophylline. Controlled release matrix tablets were prepared using different grades of Hydroxypropyl methylcellulose as matrix former and Povidone as binder. Preformulation study of drug shows that the drug has more solubility in 0.1N HCl hence it is difficult to control the drug release in gastric fluid. But a satisfactory formulation has been developed by using different grades of HPMC (Methocel K4M, Methocel K100 M, Methocel E -50 LV) for Theophylline to extend the drug release for more than 12 hours. The physicochemical compatibility of the drug with polymers was established through DSC spectroscopy. The study indicated that the drug have good compatibility with these polymers. The results of the stability studies suggested that the formulations may provide a minimum shelf life of 2 years.

Keywords: Theophylline, Hydroxypropyl methylcellulose, Povidone, Controlled release.


[Full Text Article]

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