Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF PYRAZOLINE DERIVATIVES DERIVED FROM CHALCONE

Falguni G. Bhabhor and Harish R. Dabhi*

ABSTRACT

A Chalcone was prepared by the reaction of 4-acetyl-5-methyl-2-(4- methylphenyl)-2, 4-dihydro-3H-pyrazole-3-one with different substituted aldehydes. Treatment of this Chalcone with hydrazine hydrate afforded the corresponding pyrazoline in good yields. All the new compounds have been characterized by IR, 1H-NMR, GC-MS and element analysis. The antibacterial activity of these compounds was determined with the reference of standard drug.

Keywords: Chalcone, Pyrazoline, Antibacterial activity.