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P. Sobhita Rani*, N. Srilakshmi and Singireddy Anandam


Hypertension is a chronic illness that is often undiagnosed and untreated leading to high mortality rates. The use of beta blockers such as Propranolol has been advocated as first line of therapy for the treatment of hypertension. The study and use of immediate release dosage forms for the treatment of various disease states has gained wide interest over past two decades. The use of immediate release dosage forms offers improved patient compliance and enhanced bioavailability. It also bypasses the hepatic metabolism. The current research objective was to develop buccal tablets of Propranolol for immediate release by direct compression process. Kollidon CL, Pregelatinized Starch, Glycolys were used as super disintegrants at different concentrations of 4%, 6%, 8%, 10%. The buccal tablets of Propranolol were evaluated for precompresion parameters, drug excipient compatibility studies, physical appearance, thickness, friability, weight variation, disintegration time, drug content uniformity and dissolution studies. The precompression parameters showed that, they are within the limits and the powder blends have good flow property. IR studies showed that the drug and excipients are compatible with each other. The evaluation test results of post compressed parameters showed all the parameters are within the limits. Dissolution test results revealed that formulation with 10% Kollidon CL showed greater drug release among all the formulations. Comparision between the optimized formulation (F10) and marketed product INDERAL showed better drug release from optimized formulation. The drug release followed first order kinetics. The optimized formulation was found to be stable.

Keywords: Hypertension, Propranolol, Kollidon CL, Pregelatinised Starch, Glycolys, Immediate release tablets, first order kinetics.

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