FORMULATION AND EVALUATION OF BUCCAL TABLETS OF PROPRANOLOL FOR IMMEDIATE RELEASE
P. Sobhita Rani*, N. Srilakshmi and Singireddy Anandam
ABSTRACT
Hypertension is a chronic illness that is often undiagnosed and
untreated leading to high mortality rates. The use of beta blockers such
as Propranolol has been advocated as first line of therapy for the
treatment of hypertension. The study and use of immediate release
dosage forms for the treatment of various disease states has gained
wide interest over past two decades. The use of immediate release
dosage forms offers improved patient compliance and enhanced
bioavailability. It also bypasses the hepatic metabolism. The current
research objective was to develop buccal tablets of Propranolol for
immediate release by direct compression process. Kollidon CL,
Pregelatinized Starch, Glycolys were used as super disintegrants at
different concentrations of 4%, 6%, 8%, 10%. The buccal tablets of
Propranolol were evaluated for precompresion parameters, drug
excipient compatibility studies, physical appearance, thickness, friability, weight variation,
disintegration time, drug content uniformity and dissolution studies. The precompression
parameters showed that, they are within the limits and the powder blends have good flow
property. IR studies showed that the drug and excipients are compatible with each other. The
evaluation test results of post compressed parameters showed all the parameters are within
the limits. Dissolution test results revealed that formulation with 10% Kollidon CL showed
greater drug release among all the formulations. Comparision between the optimized
formulation (F10) and marketed product INDERAL showed better drug release from
optimized formulation. The drug release followed first order kinetics. The optimized
formulation was found to be stable.
Keywords: Hypertension, Propranolol, Kollidon CL, Pregelatinised Starch, Glycolys, Immediate release tablets, first order kinetics.
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