DEVLOPMENT OF NANOSIZED ARIPIPRAZOLE LOADED BIONANOGEL USING MENTHA ARVENSIS BIOPOLYMER AS A BIOSTABILIZER CUM BIO-RETARDANT
N.V. Satheesh Madhav* and Yogita Tyagi
ABSTRACT
The current research work aimed to formulate and evaluate
Aripiprazole Bio-nanogel using Mentha arvensis as bio-retardant and
bio-stabilizer for transcranial delivery. Aripiprazole is a partial
dopamine agonist of the second generation (or atypical) class of
antipsychotics that is primarily used in the treatment of schizophrenia,
bipolar disorder, major depressive disorder (as an adjunct), and
irritability associated with autism. The biopolymer from Mentha
arvensis leaves was isolated by addition of optimized quantity of
acetone non solvent & recovered by filtration & used as bio-retardant
and bio-stabilizer & prepared Aripiprazole loaded bio-nanogel.[1] The
bio-nanogels were prepared by nanoparticle dispersion in gel method
using aripiprazole as model drug for trans-cranial delivery with
Mentha arvensis (0.1%, 0.4%, 1%, 4%) using as bio- retardant and bio-stabilizer & with
Pullulan (0.1%, 0.4%, 1%) using as standard polymer. The results were compared on
mentioned parameters like pH, texture, spreadibility, % entrapment efficacy, preliminary
determination of Nano size distribution by UV method & in-vitro drug release study. The
experimental results revealed that the formulated Aripiprazole Bio-nanogels showed T50%
of 12.9hrs and T80% of 20.7hrs respectively for FM2 (1:0.4) & T50% of 18.2hrs and T80%
of 42.3hrs respectively for FP2 (1:0.4) were found to be the best formulation showing drug
release profile in a controlled manner. The conclusion was drawn that Pudina (Mentha
arvensis) used as biopolymer was safe and developed nanosized Aripiprazole loaded bionanogel
will be more affective for brain targeting upon trans-cranial administration.
Keywords: Aripiprazole, Bio-nanogel, Pullulan, Bio-stabilizer, Bio-retardant, Mentha arvensis.
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