Abstract

DEVLOPMENT OF NANOSIZED ARIPIPRAZOLE LOADED BIONANOGEL USING MENTHA ARVENSIS BIOPOLYMER AS A BIOSTABILIZER CUM BIO-RETARDANT

N.V. Satheesh Madhav* and Yogita Tyagi

ABSTRACT

The current research work aimed to formulate and evaluate Aripiprazole Bio-nanogel using Mentha arvensis as bio-retardant and bio-stabilizer for transcranial delivery. Aripiprazole is a partial dopamine agonist of the second generation (or atypical) class of antipsychotics that is primarily used in the treatment of schizophrenia, bipolar disorder, major depressive disorder (as an adjunct), and irritability associated with autism. The biopolymer from Mentha arvensis leaves was isolated by addition of optimized quantity of acetone non solvent & recovered by filtration & used as bio-retardant and bio-stabilizer & prepared Aripiprazole loaded bio-nanogel.[1] The bio-nanogels were prepared by nanoparticle dispersion in gel method using aripiprazole as model drug for trans-cranial delivery with Mentha arvensis (0.1%, 0.4%, 1%, 4%) using as bio- retardant and bio-stabilizer & with Pullulan (0.1%, 0.4%, 1%) using as standard polymer. The results were compared on mentioned parameters like pH, texture, spreadibility, % entrapment efficacy, preliminary determination of Nano size distribution by UV method & in-vitro drug release study. The experimental results revealed that the formulated Aripiprazole Bio-nanogels showed T50% of 12.9hrs and T80% of 20.7hrs respectively for FM2 (1:0.4) & T50% of 18.2hrs and T80% of 42.3hrs respectively for FP2 (1:0.4) were found to be the best formulation showing drug release profile in a controlled manner. The conclusion was drawn that Pudina (Mentha arvensis) used as biopolymer was safe and developed nanosized Aripiprazole loaded bionanogel will be more affective for brain targeting upon trans-cranial administration.

Keywords: Aripiprazole, Bio-nanogel, Pullulan, Bio-stabilizer, Bio-retardant, Mentha arvensis.