Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

EVALUATION OF THE COMBINED EFFECTS OF CASSYTHA FILIFORMIS AND CLEISTOPHOLIS PATENS AGAINST SOME CLINICAL ISOLATES OF STAPHYLOCOCCUS AUREUS BY IN VITRO METHOD

Adonu, C.C* Enwa, F.O., Anie C.O., Gugu T, Esimone C.O., Attama A.A

1Department of Pharmaceutics, University of Nigeria, Nsukka, Enugu state, Nigeria

2Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Delta State UniversityAbraka, Nigeria.

3Department of Pharmaceutical Microbiology and Biotech, Nnamdi Azikiwe UniversityAwka, Anambra state. Nigeria.

ABSTRACT

Context: Herbalists use Cassytha filiformis Linn and Cleistopholis patens (Benth) for the treatment of urogenital infections. Objectives: The aim of this study was to evaluate the interactions of extracts from Cassytha filiformis and Cleistopholis patens leaves against Staphylococcus aureus Method: Both plants’ parts were colleccted ,shade-dried, pulverized and extracted with sterile distilled water and methanol. Extraction with water was done by 48 h maceraion while methanol was done in a Soxhlet apparatus. The extracts were concentrated and dried separately under vacuum. Gentamicin (Gentalek R) was used as a reference standard antibiotic. Preliminary antimicrobial screening of these antibacterials was carried out using agar-well diffusion techniques. Checkerboard method was used to study the combined effects of these extracts. Results: The preliminary sensitivity test showed that the water extract of Cleistopholis patens was inactive against the strains of Stapylococcus aureus tested whereas the Cassytha filiformis extracts were active against the organisms. The respective mean MIC values of the methanol extracts from Cassytha filiformis and Cleistopholis patens against Staph. aureus were 15.21 ± 0.68 and 24.62 ± 1.56 mg/ml while the water extract from Cassytha filiformis was 11.38 ± 0.99 mg/ml. The interaction studies showed that the combined effects of the extracts were predominantly indifference and antagonisms against Stapylococcus aureus. Conclusion: The extracts from these two plants should not be combined, however, can be used singly for the treatment of infections caused by Staph. aureus.

Keywords: Combined effects, Cassytha filiformis Linn, Cleistopholis patens, Staphylococcus aureus, MIC, Checkerboard method.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More