Abstract

PROTEIN AND PEPTIDE DRUG DELIVERY SYSTEM

Sagar Kishor Savale*

ABSTRACT

Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells. They exist functioning such as enzymes, hormones, structural element and immunoglobulin. The twenty different naturally occurring amino acids join with each other by peptide bonds and build polymers referred to peptides and proteins. Although the distinction between peptides and proteins are peptide contains less than 20 amino acids, having a molecular weight less than 5000, while a protein possesses 50 or more amino acids and its molecular weight lies above this value. The most of pharmaceutical proteins and peptides are absorbed IM, IV and Subcutaneous route of Absorption, but the oral route is more convenient for absorption of protein as compared to other. Various problems associated with administration of protein and peptide drugs are needed to overcome by different pharmaceutical approaches. Several approaches available for maximizing pharmacokinetic and pharmacodynamics properties are chemical modification, formulation vehicles, mucoadhesive polymeric system, use of enzyme inhibitors, absorption enhancers, penetration enhancers etc. The Present Review is described Structure, classification of Protein, Need, Advantages, Function of protein and peptide drug delivery system. Route of Absorption, Pharmaceutical approaches, Incorporation of DDS, Stability aspect, Applications, Recent Advances and Marketed formulation of Protein and Peptide drug delivery system.

Keywords: Protein, Peptide, Parenteral, Non-Parenteral, Pharmaceutical approaches, Novel drug Delivery System, immunoglobulin.