COMPARATIVE STUDY OF HUMAN BETAINE HOMOCYSTEINE METHYLTRANSFERASE ((BHMT)) BETWEEN DISEASES
Haneen M.. All-Assadii* and Dr. Shaymaa H. Al-Rajhi
ABSTRACT
For more tthan 20 years,, moderattelly raiised concenttrattiions of ttottall
homocystteiine (ttHcy) have been associiatted wiitth an iincreased riisk of
severall diiseases (attherotthrombottiic vascullar,, dementtiia,, renall faiillure,,
auttiism and lliiver) eventts butt onlly recenttlly has eviidence mountted tto
suggestt tthatt tthe associiattiion may be causall.. The associiattiion iis
iindependentt of otther facttorrs,, iitt iis faiirlly consiisttentt across many sttudiies,,
iitt iis sttrong and dose-rellatted,, and iitt iis biiollogiicalllly pllausiiblle.. However,,
tthe eviidence needs tto be sttrengtthened by a systtemattiic reviiew of allll
comparablle sttudiies and tthe demonsttrattiion,, iin randomiized ttriialls,, tthatt
lloweriing ttHcy iis follllowed by a siigniifiicantt reducttiion iin diiseases.. In
addiittiion,, tthe measurementt of ttHcy needs tto be sttandardiized.. If tthese
can be achiieved tthen ttHcy measurementt wiillll become anotther usefull marker of (diisease) riisk,,
mullttiiviittamiin ttherapy wiillll be anotther ttherapeuttiic opttiion for peoplle att riisk of speciifiic diisease..
And forttiifiicattiion of food wiitth folliic aciid wiillll riise hiigh on tthe polliittiicall and publliic healltth
agenda.. Objjecttiive: To assess homocystteiine concenttrattiion iin diifferentt diiseases as a riisk
marker for pattiientts..
Keywords: (BHMT) Bettaiine Homocystteiine Metthyllttransferase,, (Hcy) Homocystteiine,, (CVD) Cardiiovascullar Diisease.. (AD) Allzheiimer diisease..
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