Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SERIES OF 5-METHOXY-2,3-DIPHENYL-1-(5-SUBSTITUTED PHENYL -4,5 DIHYDROPYRAZOLYL)- INDOLES

Reda F. EL-Ezaby*, Farag M. Saiebb and Amal A.A. Taher

ABSTRACT

Heterocyclic compounds 5-methoxy-2,3-diphenyl-1-(5- substitutedphenyl -4,5-dihydro-1H-pyrazol-3-yl)-1H-indole (4a-4d) scheme(II) were synthesized by cyclization of chalcones 1-(5- methoxy-2,3-diphenyl-1H-indol-1-yl)-3-substitutedphenyl prop-2-en- 1-one (3a-3d) scheme (I) of indole with phenyl hydrazine in presence of base NaOH. All the synthesized compounds have been characterized by elemental (C,H,N) and spectral (I.R., 1H- NMR) analysis. Furthermore, The antibacterial activity of compounds (3a-d) and (4ad) was tested against bacterial Klebsiella pneumoniae, Esherichia coli, Proteus vulgaris, Staphylococcus aureus and Streptococcus pneumonia. Screened derivatives explored mild to moderate antibacterial inhibition.

Keywords: Indole derivatives, Pyrazoline, heterocyclic compounds, The Claisen– Schmidt condensation, biological activities.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More